Ovarian Rejuvenation: PRP & Stem Cell Therapy
Ovarian rejuvenation using PRP (Platelet-Rich Plasma) and stem cell therapy is an emerging experimental treatment that aims to restore or improve ovarian function in women with:
- Diminished ovarian reserve (DOR)
- Premature ovarian insufficiency (POI)
- Perimenopause or early menopause
- Infertility due to age-related ovarian decline
Platelet-Rich Plasma (PRP) Therapy for Ovaries
PRP is derived from the patient’s own blood. It's rich in growth factors and cytokines believed to promote tissue repair and regeneration.
Procedure:
- Blood is drawn and centrifuged to isolate the PRP.
- PRP is injected directly into the ovaries under ultrasound guidance.
Proposed Benefits:
- Stimulates dormant ovarian follicles.
- May increase estrogen production.
- May promote oocyte (egg) growth.
- Potential improvement in menstrual cycles and fertility.
Evidence:
- Mostly limited to small case studies and pilot trials.
- Some women have reported spontaneous pregnancies post-treatment.
- No large-scale, randomized controlled trials (RCTs) yet confirm effectiveness or safety.
Stem Cell Therapy for Ovarian Rejuvenation
Stem cells (often mesenchymal stem cells) may be taken from:
- Bone marrow
- Adipose (fat) tissue
- Umbilical cord (in some research settings)
Procedure:
Stem cells are harvested, processed, and injected into the ovarian tissue.
Hypothesized Mechanisms:
- Regeneration of ovarian stroma and vasculature.
- Activation of dormant follicles.
- Restoration of hormonal balance.